Names.
Can't live with 'em, and can't live without 'em.
You've got these aliens, or weird creatures, or futuristic humans, and you don't want to call them Fred. Fred doesn't seem to fit into your world- building concept; it's just a little too retro.
Well, maybe and maybe not. Remember that even in a far future story, you're translating into 20- or 21st-century English (or Spanish, Russian, or whatever). So it's not always a bad idea to use common names. But sure, use futuristic names if you like, and for your aliens you want to come up with something that sounds, well, alien. The same may be true for your place names.
But, remember your poor reader, who just might want to say the name out loud. You tell me how do you pronounce Xblmrph?
So make up names to your heart's content, but make
them pronounceable. Don't just string together a bunch of consonants and say, Whoa, alien! Try them out and see if you can pronounce them.